The impact of sex, gender and pregnancy on 2009 H1N1 disease.
The impact of sex, gender and pregnancy on 2009 H1N1 disease.
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DOI：
10.1186/2042-6410-1-5
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发表时间：
2010-11-04
影响因子：
7.9
通讯作者：
Pekosz A
中科院分区：
文献类型：
--
作者：
Klein SL;Passaretti C;Anker M;Olukoya P;Pekosz A
儿童和育龄青年已成为极易受到当前2009年H1N1流感大流行影响的群体。个体的性别是影响流感暴露、易感性和免疫反应的一个基本因素。在世界范围内，男性和女性接触2009年H1N1流感病毒后的发病率、疾病负担、发病率和死亡率各不相同，而且往往与年龄有关。怀孕和各种危险因素表现的差异导致妇女感染的结果更差。疫苗接种和抗病毒治疗效果也因性别而异。最后，性别特异性的基因和激素差异可能有助于流感的严重程度和病毒感染的清除。只有在临床和流行病学研究中更多地考虑到这些因素，并加强对这些差异背后的生物学基础的研究，才能确定性别和社会性别对流感的影响。
Children and young adults of reproductive age have emerged as groups that are highly vulnerable to the current 2009 H1N1 pandemic. The sex of an individual is a fundamental factor that can influence exposure, susceptibility and immune responses to influenza. Worldwide, the incidence, disease burden, morbidity and mortality rates following exposure to the 2009 H1N1 influenza virus differ between males and females and are often age-dependent. Pregnancy and differences in the presentation of various risk factors contribute to the worse outcome of infection in women. Vaccination and antiviral treatment efficacy also vary in a sex-dependent manner. Finally, sex-specific genetic and hormonal differences may contribute to the severity of influenza and the clearance of viral infection. The contribution of sex and gender to influenza can only be determined by a greater consideration of these factors in clinical and epidemiological studies and increased research into the biological basis underlying these differences.