Examination of the Role of Religious and Psychosocial Factors in HIV Medication Adherence Rates
Examination of the Role of Religious and Psychosocial Factors in HIV Medication Adherence Rates
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DOI：
10.1007/s10943-017-0377-1
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发表时间：
2017-12-01
影响因子：
2.8
通讯作者：
Mugoya, George
中科院分区：
文献类型：
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作者：
Dalmida, Safiya George;McCoy, Katryna;Mugoya, George
最佳的抗逆转录病毒治疗(ART)与良好的HIV结局相关，包括更高的CD4细胞计数、HIV病毒抑制和更低的HIV传播风险。然而，在美国，只有25%的艾滋病毒/艾滋病患者(PLWH)被病毒抑制。依从性不佳(90-95%)会导致抗逆转录病毒耐药性和更糟糕的医疗结果，包括更快地发展为艾滋病和死亡。心理社会因素和宗教/精神信仰(R/S)对艺术坚持有显著影响，但研究结果喜忧参半。这项研究的目的是检验宗教和心理社会的相关性和预测因素，在PLWH中90%的ART依从性。对美国东南部292名PLWH门诊患者进行了横断面研究。参与者完成了计算机化的调查。ART的平均依从率为80.9%，只有大约一半的人报告了90%的依从性。基于年龄、抑郁症状状态以及参加宗教活动和祈祷的频率，ART依从率在统计学上有显著差异。每天至少祈祷一次与90%的抗逆转录病毒治疗依从性显著相关(OR=2.26，95%CI[1.06-4.79]，p<；0.05)。社会支持满意度与抗逆转录病毒治疗依从性(OR=1.52，95%CI[1.11-2.08]，p<；0.05)和精力/疲劳/活力(OR=1.03，95%CI[1.00-1.05]，p<；0.05)显著相关。
Optimal adherence to antiretroviral therapy (ART) is associated with favorable HIV outcomes, including higher CD4 cell counts, HIV virus suppression and a lower risk of HIV transmission. However, only 25% of people living with HIV/AIDS (PLWH) in the USA are virally suppressed. Sub-optimal adherence (< 90-95%) contributes to antiretroviral resistance and worse medical outcomes, including more rapid progression to AIDS and death. Psychosocial factors and religion/spirituality (R/S) have a significant impact on ART adherence, but the findings are mixed. The purpose of this study was to examine religious and psychosocial correlates and predictors of ae90% ART adherence in PLWH. A cross-sectional study was conducted with a sample of 292 outpatient PLWH in the Southeastern USA. Participants completed computerized surveys. The mean ART adherence percentage was 80.9% and only about half reported ae90% adherence. There were statistically significant differences in ART adherence rates based on age, depressive symptom status and frequency of religious attendance and prayer. Praying at least once a day was significantly associated with ae90% ART adherence (OR = 2.26, 95% CI [1.06-4.79], p < 0.05). Social support satisfaction was also significantly associated with ART adherence (OR = 1.52, 95% CI [1.11-2.08], p < 0.05) and energy/fatigue/vitality (OR = 1.03, 95% CI [1.00-1.05], p < 0.05).