What does complement do in Alzheimer's disease? Old molecules with new insights.
What does complement do in Alzheimer's disease? Old molecules with new insights.
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DOI：
10.1186/2047-9158-2-21
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发表时间：
2013-10-12
影响因子：
12.6
通讯作者：
Li R
中科院分区：
文献类型：
--
作者：
Shen Y;Yang L;Li R
越来越多的证据表明，大脑中的炎症和免疫成分在阿尔茨海默病（AD）中很重要，抗炎和免疫治疗方法可能适用于AD治疗。众所周知，补体激活发生在AD患者的大脑中，并有助于局部炎症状态的发展，这与认知障碍有关。除了补体在先天免疫系统识别和杀伤或靶向破坏中的关键作用外，补体蛋白还可以与细胞表面受体相互作用，促进局部炎症反应，并有助于宿主的保护和愈合。另一方面，补体激活也会引起炎症和细胞损伤，作为消除细胞碎片和潜在有毒蛋白质聚集体的基本免疫功能。正是这些看似相互竞争的事件之间的平衡影响着神经元功能的最终状态。我们的小综述将集中在AD发展过程中发生的独特分子相互作用，这些相互作用的功能结果，以及每个元素对AD的贡献。
Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease (AD) and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment. It is known that complement activation occurs in the brain of patients with AD, and contributes to a local inflammatory state development which is correlated with cognitive impairment. In addition to the complement’s critical role in the innate immune system recognizing and killing, or targeting for destruction, complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the host. On the other hand, complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein aggregates. It is the balance of these seemingly competing events that influences the ultimate state of neuronal function. Our mini review will be focusing on the unique molecular interactions happening in the AD development, the functional outcomes of those interactions, as well as the contribution of each element to AD.