High-Molecular-Weight Adiponectin and Leptin Levels in Cord Blood Are Associated with Anthropometric Measurements at Birth
High-Molecular-Weight Adiponectin and Leptin Levels in Cord Blood Are Associated with Anthropometric Measurements at Birth
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DOI：
10.1159/000157872
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Tobe, Takashi
中科院分区：
文献类型：
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作者：
Inoue, Makoto;Itabashi, Kazuo;Tobe, Takashi
目的：高分子量脂联素（HMW-ad）是脂联素的一种活性形式。没有关于新生儿HMW-ad的信息。本研究的目的是检查是否HMW-AD是存在于脐带血中，以确定脐带血HMW-AD和瘦素的浓度之间的关联，以及它们与足月新生儿出生时的人体测量的相关性。方法：从135名出生于昭和大学医院的足月健康新生儿（出生体重2，261 - 4，164 g）中获得静脉脐带血样本。ELISA法测定血清总脂联素（T-ad）、高分子量脂联素（HMW-ad）和瘦素水平。结果：HMW-ad水平为14.9 +/- 5.8 μ g/ml，HMW-ad与T-ad的比值为0.49 +/- 0.15。多元逐步回归分析显示，脐血HMW-ad水平是出生体重和出生身长的显著预测因子，瘦素水平是出生体重和出生体重/身长比值的显著预测因子。在控制性别、胎龄和出生体重的情况下，HMW-ad与瘦素浓度之间存在显著相关性。结论：HMW-ad在脐血中以T-ad的一半存在。Leptin和HMW-ad可能协同调节胎儿生长。版权所有（C）2008 S. Karger AG，巴塞尔
Aims: High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether HMW-ad is present in cord blood, to define the association between the concentrations of cord blood HMW-ad and leptin, and their correlation with anthropometric measurements of term neonates at birth. Methods: Venous cord blood samples were obtained from 135 term healthy neonates (birth weight 2,261-4,164 g) born at Showa University Hospital. Total adiponectin (T-ad), HMW-ad and leptin levels were measured by ELISA. Results: HMW-ad levels were 14.9 +/- 5.8 mu g/ml and the ratio of HMW-ad to T-ad was 0.49 +/- 0.15. In a multiple regression analysis, cord blood HMW-ad levels were a significant predictor of birth weight and birth length, and leptin level was a significant predictor of birth weight and birth weight to body length ratio. There was a significant relationship between concentrations of HMW-ad and leptin controlling for sex, gestational age and birth weight. Conclusion: These results show that HMW-ad exists as a half of T-ad in the cord blood. Leptin and HMW-ad may regulate synergistically fetal growth. Copyright (C) 2008 S. Karger AG, Basel