Global phylodynamics of Echovirus 30 revealed differential behavior among viral lineages
Global phylodynamics of Echovirus 30 revealed differential behavior among viral lineages
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DOI：
10.1016/j.virol.2019.02.012
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发表时间：
2019-05-01
期刊：
影响因子：
3.7
通讯作者：
Gomez, Ricardo M.
中科院分区：
文献类型：
--
作者：
Lema, Cristina;Torres, Carolina;Gomez, Ricardo M.
Echo病毒30(E30)是世界范围内引起无菌性脑膜炎的重要病原体。尽管如此，全球和区域的扩散模式，特别是在南美洲，在很大程度上仍然是未知的。我们利用1998年至2012年在阿根廷分离的79株毒株的VP1序列和GenBank上的856株序列，对全球E30种群动态进行了深入的分析。此外，还分析了329个序列的3D(pol区)区域，以研究潜在的重组事件。E30进化的特点是随着时间的推移，谱系的共同循环和不断的更替，其中四个谱系目前似乎在循环，另外四个谱系似乎已经停止循环。五个谱系呈全球分布，而其他三个谱系的循环模式较受限。南美洲分离的毒株属于E和F两个谱系。对阿根廷毒株3D(Pol1)区的分析表明，这两个谱系都发生了重组事件。
Echovirus 30 (E30) is an important causative agent of aseptic meningitis worldwide. Despite this, the global and regional dispersion patterns, especially in South America, are still largely unknown. We performed an in-depth analysis of global E30 population dynamics, by using the VP1 sequences of 79 strains isolated in Argentina, between 1998 and 2012, and 856 sequences from GenBank. Furthermore, the 3D(pol) regions of 329 sequences were analyzed to study potential recombination events. E30 evolution was characterized by co-circulation and continuous replacement of lineages over time, where four lineages appear to circulate at present and another four lineages appear to have stopped circulating. Five lineages showed a global distribution, whereas three other lineages had a more restricted circulation pattern. Strains isolated in South America belong to lineages E and F. Analysis of the 3D(pol) region of Argentinean strains indicated that recombination events occurred in both lineages.