Health Impacts of Developmental Exposure to Environmental Chemicals
Health Impacts of Developmental Exposure to Environmental Chemicals
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DOI：
10.1007/978-981-15-0520-1
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
R. Kishi;P. Grandjean
中科院分区：
文献类型：
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作者：
R. Kishi;P. Grandjean
国际上对环境和儿童健康的关注日益增加，特别是对产前暴露于化学危害的终身健康影响的关注。本书旨在涵盖与重要的不良健康风险有关的广泛问题，以及预防可能导致早期和未来疾病的儿童不良健康风险的机会。本书由五个部分组成，《让每个人都站在健康生活的起点上》。第一部分为绪论(第一章)。它始于胎儿的水端病。已观察到严重的神经发育障碍，成人和儿童的病理表现有显著差异。胎儿水端病的病因是甲基汞。我们可以从60年前的历史中吸取教训。第二部分(环境化学品对人体发育器官的不良健康影响：化学品可能发挥的作用；2-9)由八章组成，涵盖怀孕异常、出生体重降低、出生缺陷、神经发育、免疫功能障碍、发育规划和肥胖以及生殖激素。第三部分(环境化学危害对人类发展的影响；10-16)涉及环境化学品的下一代影响，包括大气颗粒物、痕量金属、多氯联苯/二恶英、全氟化和溴化化学品、邻苯二甲酸盐和双酚。第四部分(新区研究的重要方面和预防战略；17-21)由五章组成：发育毒性的不良后果途径、暴露组学、遗传易感性、表观遗传学，最后是科学与政策之间的接口。最后，第五部分(第二章)。22)指出了环境与儿童健康研究和政策制定的进一步方向。指出了未来研究对每个人的健康生活提出的许多挑战。
The concern about the environment and children’s health is growing internationally, especially regarding the life-long health effects of prenatal exposures to chemical hazards. This book aims to cover a wide range of issues related to important adverse health risks and opportunities for the prevention of children’s adverse health risks that may lead to early and future diseases. This book consists of five parts “to make everyone stand at a starting point for a healthy life.” Part I is Introduction (Chapter 1). It begins with the fetal Minamata disease. Severe neurodevelopmental disorders have been observed with remarkable differences in pathological finding between adults and children. The cause of fetal Minamata disease was methylmercury. We can learn the lesson from the history of 60 years ago.Part II (Adverse Health Effects on Human Developing Organs Caused by Environmental Chemicals: The Role That Chemicals Might Play; Chaps. 2–9) consists of eight chapters that cover pregnancy abnormalities, decreased birth weight, birth defects, neurodevelopment, immune dysfunction, developmental programming and obesity, and reproductive hormones. Part III (Impact of Environmental Chemical Hazards on Human Development; Chaps. 10–16) deals with the next-generation effects of environmental chemicals, including atmospheric particulate matter, trace metals, PCB/Dioxins, perfluorinated and brominated chemicals, phthalates, and bisphenols. Part IV (Important Aspects of Research for Newly Developed Areas and Prevention Strategy; Chaps. 17–21) consists of five chapters: Adverse outcome pathways for developmental toxicity, exposomics, genetic susceptibility, epigenetics, and finally the interface between science and policy. Finally, Part V (Chap. 22) shows further direction of research and policy making of Environment and Children’s Health. Many challenges in the future studies are pointed out for everyone’s healthy life.