Splitting hair for cortisol? Associations of socio-economic status, ethnicity, hair color, gender and other child characteristics with hair cortisol and cortisone
Splitting hair for cortisol? Associations of socio-economic status, ethnicity, hair color, gender and other child characteristics with hair cortisol and cortisone
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DOI：
10.1016/j.psyneuen.2015.12.016
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发表时间：
2016-04-01
影响因子：
3.7
通讯作者：
van den Akker, Erica L. T.
中科院分区：
文献类型：
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作者：
Rippe, Ralph C. A.;Noppe, Gerard;van den Akker, Erica L. T.
本研究的目的是检查社会经济地位和种族与头发皮质醇和可的松的关联，并确定潜在的儿童和家庭特征，这些特征可以帮助选择协变量和潜在的混杂因素来进行涉及头发皮质醇和可的松浓度的分析。头发样本是从荷兰鹿特丹的前瞻性队列 R 一代研究中收集的 2484 名 6 岁儿童的头发样本。皮质醇和可的松的测量结果用作回归分析的结果。预测因素包括社会经济地位、种族、头发颜色和儿童特征，如出生体重、出生胎龄、体重指数、疾病、过敏和药物使用。较低的家庭收入、更多的孩子需要靠这种收入养活、较高的体重指数和较深的头发颜色与较高的头发皮质醇和可的松水平有关。男孩也表现出更高的水平。种族（荷兰和北欧血统）与较低水平有关。采毛月份的大量阳光仅与较高水平的可的松有关。最近洗头与皮质醇和可的松水平较低有关。出生胎龄、出生体重、年龄、药物使用、洗发频率、母亲的教育水平、母亲的婚姻状况、疾病和过敏与皮质醇或可的松水平无关。我们的结果可以作为在实质性预测变量或结果的研究中选择协变量和混杂因素的起点。强烈建议考虑性别、BMI、收入、家庭人数、种族、头发颜色和最近洗头的情况。 (C) 2015 Elsevier Ltd. 保留所有权利。
The aim of this study was to examine associations of SES and ethnicity with hair cortisol and cortisone and to identify potential child and family characteristics that can assist in choosing covariates and potential confounders for analyses involving hair cortisol and cortisone concentrations. Hair samples were collected in 2484 6-year-old children from the Generation R Study, a prospective cohort in Rotterdam, the Netherlands. Measurements for cortisol and cortisone were used as the outcome in regression analyses. Predictors were SES, ethnicity, hair color and child characteristics such as birthweight, gestational age at birth, BMI, disease, allergy, and medication use. Lower family income, more children to be supported by this income, higher BMI and darker hair color were associated with higher hair cortisol and cortisone levels. Boys also showed higher levels. Ethnicity (Dutch and North European descent) was related to lower levels. High amounts of sun in the month of hair collection was related to higher levels of cortisone only. More recent hair washing was related to lower levels of cortisol and cortisone. Gestational age at birth, birth weight, age, medication use, hair washing frequency, educational level of the mother, marital status of the mother, disease and allergy were not associated with cortisol or cortisone levels. Our results serve as a starting point for choosing covariates and confounders in studies of substantive predictors or outcomes. Gender, BMI, income, the number of persons in a household, ethnicity, hair color and recency of hair washing are strongly suggested to take into account. (C) 2015 Elsevier Ltd. All rights reserved.