GLIAL CELL-PROLIFERATION IN RETINAL-DETACHMENT (MASSIVE PERIRETINAL PROLIFERATION)
GLIAL CELL-PROLIFERATION IN RETINAL-DETACHMENT (MASSIVE PERIRETINAL PROLIFERATION)
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DOI：
10.1016/0002-9394(75)90390-6
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发表时间：
1975-01-01
影响因子：
4.2
通讯作者：
MACHEMER, R
中科院分区：
文献类型：
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作者：
LAQUA, H;MACHEMER, R
在猫头鹰猴的实验性视网膜脱离中，我们观察到视网膜前膜和视网膜下膜的形成，这些膜与视网膜本身有细胞连接。基于光学显微镜的发现，我们得出结论，视网膜细胞生长出视网膜，并建立视网膜前和视网膜下组织。电子显微镜下，这些细胞被鉴定为星形胶质细胞，它们通过内界膜或外界膜中的局灶性中断生长出来。在生长的直接区域，Muller细胞突起参与视网膜前或视网膜下组织的形成。这些神经胶质膜可引起内界膜和神经纤维层的折叠或视网膜的全层折叠。胶质细胞增生在视网膜脱离并发症的发展中起着重要作用，我们建议将其称为“大规模视网膜周围增生”（MPP）。
In experimental retinal detachment of the owl monkey we observed the formation of preretinal and subretinal membranes which had cellular connections to the retina proper. Based on light microscopic findings we concluded that retinal cells grow out of the retina and build up the preretinal and subretinal tissue. Electron microscopically these cells are identified as astrocytes which grow out through focal interruptions in the internal or external limiting membrane. In the immediate area of outgrowth Muller cell processes praticipate in the formation of the preretinal or subretinal tissue. These glial membranes can cause wrinkling of the internal limiting membrane and the nerve fiber layer or full-thickness folding of the retina. Glial proliferation plays an important role in the development of a complication in retinal detachment which we suggest calling" massive periretinal proliferation"(MPP).