Racial differences in a prostate cancer screening study
Racial differences in a prostate cancer screening study
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DOI：
10.1016/s0022-5347(01)65588-5
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发表时间：
1996-10-01
影响因子：
6.6
通讯作者：
Herschman, JD
中科院分区：
文献类型：
--
作者：
Smith, DS;Bullock, AD;Herschman, JD
目的：我们试图确定黑人是否患有更高的前列腺癌患病率和更晚期的疾病。材料和方法：我们通过血清前列腺特异性抗原测量和直肠指检筛查了 17,157 名 50 岁或以上的白人和 804 名黑人男性。当任一测试可疑时，我们建议进行活检。 结果：黑人男性前列腺特异性抗原升高（13.1% vs 8.9%）和癌症（5.1% vs 3.2%）的患病率高于白人，并且临床晚期癌症的患病率较高，但病理晚期癌症的患病率较高。低收入邮政编码地区的黑人男性遵守活检建议的人数较少。结论：在我们的筛查研究中，黑人男性的可检测癌症患病率较高。然而，与临床研究不同的是，诊断时的晚期癌症阶段没有显着的种族差异。
Purpose: We attempted to determine whether black men have a higher prostate cancer prevalence and more advanced disease.Materials and Methods: We screened 17,157 white and 804 black men 50 years old or older by serum prostate specific antigen measurement and digital rectal examination. We recommended biopsy when either test was suspicious.Results: Black men had a higher prevalence of elevated prostate specific antigen (13.1 versus 8.9%) and cancer (5.1 versus 3.2%) than white men, and a higher prevalence of clinically but not pathologically advanced cancer. Fewer black men in lower income zip codes complied with recommendations for biopsy.Conclusions: In our screening study black men had a higher prevalence of detectable cancer. However, unlike in clinical studies there was no striking racial difference in advanced cancer stage at diagnosis.