Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study
Annual incidence rate of schizophrenia and schizophrenia spectrum disorders in a longitudinal population-based cohort study
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基于人群的纵向队列研究中精神分裂症和精神分裂症谱系障碍的年发病率
DOI：
10.1007/s00127-013-0651-9
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发表时间：
2013
影响因子：
4.4
通讯作者：
M. Sturkenboom
中科院分区：
文献类型：
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作者：
A. Sutterland;J. Dieleman;J. Storosum;B. Voordouw;Jojanneke S Kroon;J. Veldhuis;D. Denys;L. Haan;M. Sturkenboom
精神分裂症谱系障碍（SSD）在精神卫生服务机构中的纵向发病率研究容易受到在一般人群中进行的研究中没有发现的混杂因素的影响。（广义）和精神分裂症（狭义）在一般人群中，并分析相关的危险因素。（1996-2006）在一个大型的全科医生研究数据库进行了纵向医疗记录的350,524例患者在整个荷兰。通过对病历的系统回顾，对SSD病例进行识别和分类。年龄和性别特异性IRs计算每个日历年，出生日期，城市化程度和deprivation.ResultsOverall IR SSD在这一人群中为22/100，000人年（PY）（95%CI 19-24）。精神分裂症的IR为12/100，000 PY（95% CI 10-14）。期间患病率为3.5/1，000 PY。与女性相比，男性的IR更高，在15-25岁时达到峰值，25岁后迅速下降，每10年下降40%。无论贫困程度如何，城市地区的SSD IR显着更高。SSD的IR与生活在贫困地区或出生月份之间没有关联。有没有显着的时间趋势的IR在此期间study. ConclusionsIR的SSD是在城市地区，独立的社会剥夺。IR存在年龄和性别特异性差异，这些差异在狭义精神分裂症中的程度大于SSD。
BackgroundLongitudinal incidence studies of schizophrenia spectrum disorders (SSD) performed in mental health service organizations are prone to confounding factors not found in research performed in the general population.ObjectivesTo estimate the incidence rates (IRs) over a 10-year period of SSD (broadly defined) and schizophrenia (narrowly defined) in the general population and to analyze associated risk factors.MethodsA cohort study (1996–2006) in a large general practitioners research database was conducted with longitudinal medical records of 350,524 patients throughout the Netherlands. Cases of SSD were identified and classified by systematic review of medical records. Age- and gender-specific IRs were calculated per calendar year, date of birth, degree of urbanicity and deprivation.ResultsOverall IR of SSD in this population was 22/100,000 person years (PY) (95 % CI 19–24). IR of schizophrenia was 12/100,000 PY (95 % CI 10–14). Period prevalence was 3.5 per 1,000 PY. IRs were higher in men compared to women, had a peak at age 15–25 years, decreasing rapidly after 25 years by 40 % per 10 years. IRs of SSD were significantly higher in urban areas, irrespective of deprivation. No association was found between IRs of SSD and living in deprived areas or month of birth. There was no significant time trend of the IR during the period under study.ConclusionsIRs of SSD are higher in urban areas, independent of social deprivation. Age- and gender-specific differences in IR were found. The magnitude of these differences was larger in narrowly defined schizophrenia than in SSD.
影响因子：
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作者：
K. Kendler;Timothy J. Gallagher;J. Abelson;Ronald C. Kessler
通讯作者：
K. Kendler;Timothy J. Gallagher;J. Abelson;Ronald C. Kessler