EFFECT OF AGE ON BONE-DENSITY AND BONE TURNOVER IN MEN
EFFECT OF AGE ON BONE-DENSITY AND BONE TURNOVER IN MEN
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DOI：
10.1111/j.1365-2265.1995.tb01854.x
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发表时间：
1995-02-01
影响因子：
3.2
通讯作者：
NORDIN, BEC
中科院分区：
文献类型：
--
作者：
WISHART, JM;NEED, AG;NORDIN, BEC
目的：对男性年龄相关性骨丢失的模式知之甚少，尽管雄激素是最佳骨量所必需的，但尚不清楚男性骨量随年龄的下降是否与雄激素的下降有关。设计：对147名年龄在20-83岁的正常志愿者的5个部位的骨密度和骨吸收和形成的标志物进行横断面测量。医院工作人员、他们的亲属和参加我们骨质疏松症诊所的妇女的丈夫。（脂肪校正），脊柱L2-L4，股骨颈，沃德三角和转子密度;血清前胶原I C-末端延伸肽，骨钙素，骨碱性磷酸酶和胶原I C-末端端肽;空腹尿羟脯氨酸/肌酐，吡啶啉/肌酐和脱氧吡啶啉/肌酐;和游离雄激素指数（FAI），测量血清睾酮/性激素结合球蛋白。从第三个十年开始，固定资产投资显著下降。所有骨标志物的水平下降，随着年龄的增长。结论男性骨质流失似乎从50岁加速，并与骨形成减少，这可能与游离雄激素水平下降。
OBJECTIVE Little is known about the pattern of age-related bone loss in men, and although androgens are required for optimum bone mass it is not clear whether the fall in bone mass with age in men Is related to falling androgens.DESIGN Cross-sectional measurement of bone density, at five sites, and markers of bone resorption and formation in 147 normal volunteers aged 20-83 years.SUBJECTS Healthy laboratory workers, hospital staff, their relatives, and husbands of women attending our osteoporosis clinic.MEASUREMENTS Forearm density (fat corrected), spine L2-L4, femoral neck, Ward's triangle and trochanter density; serum procollagen I C-terminal extension peptide, osteocalcin, bone alkaline phosphatase and collagen I C-terminal telopeptide; fasting urine hydroxyproline/creatinine, pyridinoline/creatinine and deoxypyridinoline/creatinine; and free androgen index (FAI), measured as serum testosterone/sex hormone binding globulin.RESULTS Bone loss accelerated at most sites after age 50. There was a significant fall in FAI from the third decade onwards. The levels of all bone markers fell with age.CONCLUSIONS Bone loss in men appears to accelerate from age 50 and is associated with decreased bone formation which may be associated with falling levels of free androgen.