Immune cell infiltrates and prognosis in primary carcinoma of the lung
Immune cell infiltrates and prognosis in primary carcinoma of the lung
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DOI：
10.1016/s0169-5002(99)00095-1
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发表时间：
2000-01-01
期刊：
影响因子：
5.3
通讯作者：
Jeffrey, RR
中科院分区：
文献类型：
--
作者：
Johnson, SK;Kerr, KM;Jeffrey, RR
本文对710例手术切除的人肺癌免疫细胞浸润物的预后意义进行了研究，并对95例肺癌患者的淋巴浸润物进行了免疫组化染色和亚群定量。用免疫组织化学和CD3、CD8、CD57、CD68、CD79a和S100抗体鉴定各种免疫细胞类型。淋巴系统的主观分级(低、中、高)：肿瘤HE切片上有细胞浸润，免疫组织化学标记的免疫细胞类型中的任何一种用图像分析来测量肿瘤的总体浸润水平并无预后意义，但当按特定细胞类型区分瘤周和瘤内浸润时，高水平的CD3(+)和S100(+)细胞与术后较长的生存期相关(分别为P=0.02和P=0.045)。在肺癌中，特定免疫细胞类型对肿瘤淋巴组织浸润和总体水平的主观评估没有预后意义，相对较高数量的CD3(+)T淋巴细胞和朗格汉斯细胞(S100(+))的肿瘤内浸润与较好的患者预后相关。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
The prognostic significance of immune cell infiltrates in surgically resected human lung cancer was investigated in 710 patients, Lymphoid infiltrates were quantified on both standard H&E stained sections and, in a subset of 95 cases. using immunohistochemistry and antibodies to CD3, CD8, CD57, CD68 CD79a and S100 to identify various immune cell types. Subjective grading (low, moderate, high) of lymphoid: cell-infiltrates on H&E sections of tumour and measurement, using image analysis, of overall level of tumour infiltration by any of the immunohistochemically labelled specific immune cell types of the stained sections showed no prognostic significance, However, when a distinction between peritumoural and intratumoural infiltration by particular cell types was made, intratumoural infiltration by high levels of CD3(+) and S100(+) cells was associated with longer post-operative survival (P = 0.02 and P = 0.045, respectively). In lung cancer, subjective assessment of tumour lymphoid infiltration and overall levels of infiltration by particular immune cell types carries no prognostic significance, Intratumoural infiltration by relatively high numbers of CD3(+) T-lymphocytes and Langerhans cells (S100(+)) is associated with a better patient outcome. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.