Going in GTP cycles in the nucleolus.
Going in GTP cycles in the nucleolus.
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DOI：
10.1083/jcb.200412038
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发表时间：
2005-01-17
影响因子：
7.8
通讯作者：
Misteli, Tom
中科院分区：
文献类型：
--
作者：
Misteli, Tom
蛋白质通过特定的定位信号引导至细胞区室。 GTP 驱动的循环现已被确定为蛋白质靶向核仁的机制。 GTP 开关的参与表明核仁定位可以被调节，并且可能通过信号通路对细胞外刺激做出反应。未发现的机制还意味着定位是由增加的保留而不是定向靶向决定的。
Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.