Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.
Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study.
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单侧急性开放性球损伤患者的区域均匀性改变：静息态功能 MRI 研究
DOI：
10.2147/ndt.s110541
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发表时间：
2016
影响因子：
3.2
通讯作者：
Shao Y
中科院分区：
文献类型：
--
作者：
Huang X;Li HJ;Ye L;Zhang Y;Wei R;Zhong YL;Peng DC;Shao Y
目的探讨单侧急性开放球损伤（OGI）患者潜在的区域均匀性（ReHo）脑活动变化及其与临床特征的关系。患者与方法共纳入18例急性OGI患者（男16例，女2例）和18例年龄、性别、受教育程度相近的健康对照（hc，男16例，女2例）。每个受试者都进行了静息状态功能磁共振成像扫描。采用ReHo方法评估自发性脑活动的局部特征。接受者工作特征曲线用于区分ogi和hc。采用非参数统计分析方法探讨观察到的不同脑区平均ReHo值与行为表现的关系。结果与hc相比，急性OGI患者右侧小脑后叶/舌回、左侧颞上回/额下回、左侧额下回、左侧后扣带皮层/楔前叶、左侧中央前盖的ReHo值明显升高。然而，观察到的不同脑区的平均ReHo值与行为表现之间没有关系。结论急性OGI可引起多脑区功能障碍，这可能反映了OGI患者急性视力丧失的潜在病理机制。
Objective To investigate the underlying regional homogeneity (ReHo) brain activity changes in patients with unilateral acute open-globe injury (OGI) and their relationship with their clinical features. Patients and methods In total, 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs; 16 males and two females) closely matched in age, sex, and education status participated in the study. Each subject underwent a resting-state functional magnetic resonance imaging scan. The ReHo method was used to assess local features of spontaneous brain activity. Receiver–operating characteristic curve was used to distinguish OGIs from HCs. The nonparametric statistical analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the behavioral performance. Results Compared with HCs, acute OGI patients had significantly increased ReHo values in the right cerebellum posterior lobe/lingual gyrus, left superior temporal gyrus/inferior frontal gyrus, left inferior frontal gyrus, left posterior cingulate cortex/precuneus, and left precentral operculum. However, there was no relationship between the observed mean ReHo values of the different brain areas and the behavioral performance. Conclusion Acute OGI may cause dysfunction in many brain regions, which may reflect the underlying pathologic mechanisms of acute vision loss in OGI patients.