Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
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DOI：
10.1002/ana.1254.abs
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发表时间：
2001-11-01
影响因子：
11.2
通讯作者：
Nixon, R
中科院分区：
文献类型：
--
作者：
Cataldo, A;Rebeck, GW;Nixon, R
内吞途径在淀粉样蛋白前体蛋白（APP）加工和β -淀粉样蛋白形成中起重要作用。我们的研究表明，在散发性阿尔茨海默病中，内吞通路激活是大脑脆弱区域神经元的一个突出的早期特征。我们报道，在某些APP突变引起的阿尔茨海默病中，内吞通路异常不仅存在于神经元中，而且存在于脑内皮中。内吞异常的存在与否区分了与APP突变相关的家族性阿尔茨海默病亚型和早老素突变，支持了不同的细胞途径参与APP加工的改变，从而导致某些不同阿尔茨海默病亚型中β -淀粉样蛋白生成增加的观点。
The endocytic pathway is important in amyloid precursor protein (APP) processing and beta -amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerable regions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebral endothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased beta -amyloid generation in certain of these different Alzheimer's disease subtypes.