Principles of mimicking and engineering the self-organized structure of hard tissues
Principles of mimicking and engineering the self-organized structure of hard tissues
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DOI：
10.1074/jbc.m314027200
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发表时间：
2004-10-01
影响因子：
4.8
通讯作者：
Liu, XY
中科院分区：
文献类型：
--
作者：
Jiang, HD;Liu, XY
研究了羟基磷灰石（HAP）纳米晶结构的形成机理。发现HAP纳米晶的高度有序组装归因于所谓的自（homo）外延形核和生长。另一方面，根据这一机制，高过饱和度会引起HAP晶体的随机组装。研究了离子、生物底物和过饱和对底物和生物矿物质之间微/纳米结构相关性的影响，以及它们对硬组织形成的影响。令人惊讶的是，一些生物分子被发现能够抑制过饱和驱动的界面结构错配，从而促进排列良好的HAP模式的形成。
The mechanism of the formation of a self-aligned hydroxyapatite (HAP) nanocrystallite structure was examined. It is found that the highly ordered HAP nanocrystallite assembly is attributed to the so-called self(homo)epitaxial nucleation and growth. On the other hand, according to this mechanism, a high supersaturation will give rise to a random assembly of HAP crystallites. The effects of ions, biosubstrate, and supersaturation on the micro/nanostructure correlation between substrate and biominerals as well as their implications in hard tissue formation were examined. Surprisingly, some biomolecules are found to be able to suppress the supersaturation-driven interfacial structure mismatch and hence promote the well aligned HAP pattern formation.