Unique features of DNA replication in mitochondria: A functional and evolutionary perspective
Unique features of DNA replication in mitochondria: A functional and evolutionary perspective
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DOI：
10.1002/bies.201400052
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发表时间：
2014-11-01
期刊：
影响因子：
4
通讯作者：
Jacobs, Howard T.
中科院分区：
文献类型：
--
作者：
Holt, Ian J.;Jacobs, Howard T.
去年，我们报道了哺乳动物DNA复制的新机制。它发生在线粒体内，需要使用加工的转录物，称为靴带，随着复制叉的前进，靴带与被取代的亲本链杂交。在这里，我们讨论可能的原因，为什么这样一个不寻常的DNA复制机制可能已经演变。靴带机制可以最小化单链断裂的发生和影响，否则会威胁基因组稳定性。此外，通过提供隐式错配识别系统，它应该限制复制依赖性缺失和插入的发生，并防御入侵元件。这种机制也可能限制操纵哺乳动物线粒体基因组的尝试。
Last year, we reported a new mechanism of DNA replication in mammals. It occurs inside mitochondria and entails the use of processed transcripts, termed bootlaces, which hybridize with the displaced parental strand as the replication fork advances. Here we discuss possible reasons why such an unusual mechanism of DNA replication might have evolved. The bootlace mechanism can minimize the occurrence and impact of single-strand breaks that would otherwise threaten genome stability. Furthermore, by providing an implicit mismatch recognition system, it should limit the occurrence of replication-dependent deletions and insertions, and defend against invading elements. Such a mechanism may also limit attempts to manipulate the mammalian mitochondrial genome.