Inducible erythromycin resistance in bacteria.
Inducible erythromycin resistance in bacteria.
复制标题
细菌诱导红霉素耐药性。
DOI：
10.1093/oxfordjournals.bmb.a071947
复制
发表时间：
1984
影响因子：
6.7
通讯作者：
Weisblum,B
中科院分区：
文献类型：
--
作者：
Weisblum,B
Erythromycin belongs to the class of macrolides, a group of antibiotics which exert their inhibitory effect on bacterial growth by specifically binding to the 50S ribosome subunit and inhibiting protein synthesis. The introduction of erythromycin into medical practice1 was followed by reports from France, UK, and USA during 1956-19572" 4 of erythromycin-resistant Staphylococcus aureus. What appeared initially as uncomplicated resistance to erythromycin in gram-positive bacteria has actually been found to constitute a resistance syndrome, dependent upon biochemical modification of the 50S ribosome subunit which, in turn, confers resistance to three chemically distinct classes of antibiotics—the macrolides, lincosamides, and streptogramin type-B (MLS) antibiotics.That expression of staphylococcal MLS resistance is inducible poses provocative questions in the research laboratory and potential problems in the clinic. In many, but not all, clinical isolates the gene which confers resistance is not expressed until the bacterium encounters subinhibitory concentrations of the drug. The chain of molecular events whereby 5. aureus senses inducing concentrations of drug and specifically processes the information so as to render the cell phenotypically resistant will be the subject of this review.
