THE CURVATURE ELASTIC-ENERGY FUNCTION OF THE LIPID-WATER CUBIC MESOPHASE
THE CURVATURE ELASTIC-ENERGY FUNCTION OF THE LIPID-WATER CUBIC MESOPHASE
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DOI：
10.1038/368224a0
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发表时间：
1994-03-17
期刊：
影响因子：
64.8
通讯作者：
CAFFREY, M
中科院分区：
文献类型：
--
作者：
CHUNG, H;CAFFREY, M
细胞和脂质膜能够弯曲，如膜融合和水中非层状溶致中间相的形成过程中所表现的那样。但脂质层的弯曲会产生能量成本，称为曲率弹性能。尽管这种能量的函数形式是已知的(1)，但仍缺乏对曲率弹性能的完整定量了解，而曲率弹性能对于预测脂质膜可采用的大量相的相对稳定性至关重要。在这里，我们使用 X 射线同步加速器衍射测量水合单油酸甘油酯周期性 Ia3d (Q(230)) 立方相的晶格参数随压力和温度的变化来计算脂质立方中间相的完整曲率弹性能量函数。这使我们能够预测该系统不同立方相和层状相的稳定性作为组成的函数。
CELL and lipid membranes are able to bend, as manifested during membrane fusion and the formation of non-lamellar lyotropic mesophases in water. But there is an energy cost to bending of lipid layers, called the curvature elastic energy. Although the functional form of this energy is known(1), a complete quantitative knowledge of the curvature elastic energy, which is central to predicting the relative stability of the large number of phases that lipid membranes can adopt, has been lacking. Here we use X-ray synchrotron diffraction measurements of the variation of lattice parameter with pressure and temperature for the periodic Ia3d (Q(230)) cubic phase of hydrated monoolein to calculate the complete curvature elastic-energy function for the lipid cubic mesophase. This allows us to predict the stabilities of different cubic and lamellar phases for this system as a function of composition.