Teratogenic effects of the Zika virus and the role of the placenta
Teratogenic effects of the Zika virus and the role of the placenta
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DOI：
10.1016/s0140-6736(16)00650-4
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发表时间：
2016-04-09
期刊：
影响因子：
168.9
通讯作者：
Beigi, Richard H.
中科院分区：
文献类型：
--
作者：
Adibi, Jennifer J.;Marques, Ernesto T. A., Jr.;Beigi, Richard H.
寨卡病毒引起胎儿小头畸形的机制尚不清楚。报告表明，寨卡病毒能够逃避胎盘的正常免疫保护反应。小头畸形有遗传原因，有些与母体暴露有关，包括辐射，烟草烟雾，酒精和病毒。关于胎盘的作用有两种可能的假设：一种是胎盘直接将寨卡病毒传播给早期胚胎或胎儿。或者，胎盘本身可能对暴露产生反应;这种反应可能导致或导致大脑缺陷。这种区别对于诊断有风险的胎儿和设计预防寨卡病毒诱导的致畸作用的治疗策略至关重要。
The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus. Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing to or causing the brain defect. This distinction is crucial to the diagnosis of fetuses at risk and the design of therapeutic strategies to prevent Zika-induced teratogenesis.