Regional cerebral blood flow of patients with focal epilepsy studied using xenon enhanced CT brain scanning.
Regional cerebral blood flow of patients with focal epilepsy studied using xenon enhanced CT brain scanning.
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使用氙增强 CT 脑部扫描研究局灶性癫痫患者的局部脑血流。
DOI：
10.1136/jnnp.50.12.1584
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
B. Kendall
中科院分区：
文献类型：
--
作者：
D. Fish;T. Lewis;D. Brooks;E. Zilkha;R. Wise;B. Kendall
应用稳定氙增强X线计算机断层扫描（XeCT）对12例脑电图（EEG）显示明显单侧病灶的耐药部分性癫痫患者进行局部脑血流量（rCBF）测定。与对侧相同区域相比，致癫痫大脑叶皮质中固定感兴趣区域（ROI）的发作间期平均rCBF降低了25%（p <0.02）。6个对照扫描显示，平均侧到侧的皮质差异rCBF的14%，而致痫灶与皮质rCBF的减少大于30%的12例中的6例。在另外一例部分性癫痫患者中，发作间期EEG和常规CT扫描显示无异常时，XeCT显示明显的局灶性灌注不足。
Stable xenon-enhanced X-ray computed tomography (XeCT) was used to measure the regional cerebral blood flow (rCBF) of 12 patients with drug resistant partial epilepsy and a marked unilateral focus on electroencephalography (EEG). Interictal mean rCBF of fixed regions of interest (ROIs) was reduced by 25% in the cortex of the epileptogenic cerebral lobe compared with the same regions on the contralateral side (p less than 0.02). Six control scans showed a mean side to side cortical difference in rCBF of 14%, whereas the epileptogenic focus was associated with a reduction in the cortical rCBF of greater than 30% in six out of the 12 patients. In an additional patient with partial epilepsy XeCT demonstrated significant focal hypoperfusion when interictal EEGs and conventional CT scans showed no abnormalities.