Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy
Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy
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DOI：
10.1002/ana.20334
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发表时间：
2005-02-01
影响因子：
11.2
通讯作者：
Gross, DW
中科院分区：
文献类型：
--
作者：
Concha, L;Beaulieu, C;Gross, DW
扩散张量磁共振成像可以获得关于白色物质结构的微结构完整性的定量信息，并基于水扩散行为描绘活体脑连接。扩散张量成像衍生纤维束成像已用于健康受试者的穹窿和扣带回的虚拟解剖，但未用于颞叶癫痫（TLE）患者。8例难治性颞叶癫痫和单侧颞叶内侧硬化症患者和9例健康对照者采用扩散张量成像。采用纤维追踪法描绘穹窿和扣带回，并对其进行定量分析。在TLE患者的穹窿中观察到分数各向异性的双侧对称性降低，以及垂直于纤维轴的水流动性增加。在扣带回的结果是类似的穹窿，除了显着增加的体积扩散率在后者。我们在一系列单侧颞叶内侧硬化症患者中观察到穹窿和扣带回轴索完整性的显著对称性双侧异常。我们的研究结果表明，颞叶癫痫伴单侧颞叶内侧硬化与双侧边缘系统的病理。
Diffusion tensor magnetic resonance imaging can acquire quantitative information on the microstructural integrity of white matter structures and depict brain connectivity in vivo based on the behavior of water diffusion. Diffusion tensor imaging-derived tractography has been used for virtual dissection of the fornix and cingulum in healthy subjects, but not in patients with temporal lobe epilepsy (TLE). Eight patients with medically intractable TLE and unilateral mesial temporal sclerosis and nine healthy control subjects were imaged using diffusion tensor imaging. Fiber tracking was performed to delineate the fornix and cingulum, which were quantitatively analyzed. Bilateral symmetrical reduction in fractional anisotropy was observed in the fornix of patients with TLE, together with an increase in water mobility perpendicular to the axis of the fibers. The findings in the cingulum are similar to those of the fornix with the exception of significantly increased bulk diffusivity in the latter. We observed strikingly symmetrical bilateral abnormalities of axonal integrity in the fornix and cingulum in a series of patients with unilateral mesial temporal sclerosis. Our findings suggest that TLE with unilateral mesial temporal sclerosis is associated with bilateral limbic system pathology.