Regulatory T Lymphocytes in Periodontitis: A Translational View.
Regulatory T Lymphocytes in Periodontitis: A Translational View.
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DOI：
10.1155/2018/7806912
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发表时间：
2018
影响因子：
4.6
通讯作者：
Vernal R
中科院分区：
文献类型：
--
作者：
Alvarez C;Rojas C;Rojas L;Cafferata EA;Monasterio G;Vernal R
牙周炎是一种慢性免疫炎症性疾病，其中宿主和微生物群相互作用之间的平衡的破坏是疾病发生和进展的关键。与牙周健康相关的免疫稳态需要调节的免疫炎症反应，在此期间，调节性T细胞（TCFs）的存在对于确保最大限度地减少附带组织损伤的受控反应至关重要。由于Treg调节先天免疫和适应性免疫两者，因此可以通过获得免疫耐受来解决的病理状况，例如牙周炎，可以通过使用Treg免疫疗法而受益。近年来，人们提出了许多策略来利用Treg的免疫抑制能力作为免疫疗法，包括对Treg区室的离体和体内操作。基础研究和转化研究的持续研究让我们更好地了解Treg亚群的多样性、其表型可塑性和抑制功能，这些可用作新免疫疗法的底物。当然，随着我们对Treg生物学知识的增加，我们将能够开发旨在增强牙周炎期间Treg稳定性和功能的新疗法。
Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.
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影响因子：
7.3
作者：
Goldstein JD;Pérol L;Zaragoza B;Baeyens A;Marodon G;Piaggio E
通讯作者：
Piaggio E
DOI：
10.1073/pnas.0509484103
发表时间：
2006-04-25
影响因子：
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作者：
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作者：
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影响因子：
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