Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais
Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais
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DOI：
10.1034/j.1399-0039.2002.590206.x
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发表时间：
2002-02-01
期刊：
影响因子：
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通讯作者：
Tokunaga, K
中科院分区：
文献类型：
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作者：
Sirikong, M;Tsuchiya, N;Tokunaga, K
在这项研究中，我们调查了HLA-DPB 1和DQB 1与泰国SLE患者的关联。SLE患者DPB 1 *1502和DQB 1 *0501基因频率显著高于正常对照组。DRB 1 *1501和DRB 1 *1602也略有增加。而患者组DPB 1 *1202、DQB 1 *0301降低，DPB 1 *0406、DPB 1 *1401未检出。单倍型分析显示DRB 1 *1502 -DQB 1 *0501是最常见的单倍型，也表明DRB 1而不是DQB 1在SLE的发病中起主要作用。结合先前在台湾发现的相同单倍型的相关性，我们目前的观察结果强烈提示DPB 1 *1502 -DQB 1 *0501是东南亚人群中SLE易感性的主要HLA单倍型。
In this study, we investigated the association of HLA-DPB1 and DQB1 with Thai patients with SLE. A highly significant increase in the frequency of DPB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls. DRB1*1501 and DRB1*1602 were also slightly increased. In contrast, DPB1*1202 and DQB1*0301 were decreased, and DPB1*0406 and DPB1*1401 were not found in the patients' group. The haplotype analysis revealed that DRB1*1502 - DQB1*0501 was Most and also suggested a primary role for DRB1 strongly associated with SLE, rather than DQB1. Taken together with the previous report which demonstrated the association of the same haplotype in Taiwan, our present observations strongly suggested that DPB1*1502 - DQB1*0501 is the major HLA haplotype that confers susceptibility to SLE in the South-east Asian populations.