Mass transport enhancement by ultrasound in non-degradable polymeric controlled release systems
Mass transport enhancement by ultrasound in non-degradable polymeric controlled release systems
复制标题
DOI：
10.1016/s0168-3659(97)00112-0
复制
发表时间：
1998-06-01
影响因子：
10.8
通讯作者：
Kost, J
中科院分区：
文献类型：
--
作者：
Lavon, I;Kost, J
在这项工作中，试图在非易蚀性聚合物基质中表征质量传递增强，由超声引起。发现暴露于超声的聚合物基质的药物释放速率可以通过改变参数来控制，所述参数如：超声频率、掺入药物的分子量和聚合物基质的结构（网络中孔的尺寸）。有人建议，从非侵蚀性聚合物的药物释放的超声的增强效果是由于对流项的贡献，由空化产生的，没有任何破坏性的影响的形态的聚合物。这种现象被发现是更明显的系统中的质量传输限制。(C)1998年Elsevier Science B.V.
In this work, an attempt was made to characterize mass transport enhancement in non-erodible polymeric matrices, caused by ultrasound. It was found that drug release rates from polymeric matrices exposed to ultrasound, can be controlled by modifying parameters like: ultrasound frequency, molecular weight of the incorporated drug and structure of the polymeric matrix (size of pores in the network). It is suggested that the enhancing effect of ultrasound on drug release from non-erodible polymers is due to the contribution of a convective term, generated by cavitation, without any destructive effect on morphology of the polymer. This phenomenon was found to be more pronounced in systems which are mass-transport limited. (C) 1998 Elsevier Science B.V.