Organocatalytic amidation and esterification of aldehydes with activating reagents by a cross-coupling strategy.
Organocatalytic amidation and esterification of aldehydes with activating reagents by a cross-coupling strategy.
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DOI：
10.1002/anie.201205921
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发表时间：
2012-12
影响因子：
--
通讯作者：
B. Tan;N. Toda;C. Barbas
中科院分区：
文献类型：
--
作者：
B. Tan;N. Toda;C. Barbas
按需组建：研究了醛与N-羟基酰亚胺、六氟异丙醇和磺酰亚胺的有机催化交叉偶联反应。所得的活性中间体可以在一锅中直接转化为酰胺或酯。这种简单的方法利用容易获得的起始原料，新发现的活化剂应该在酰胺和酯的合成中找到广泛的应用。
Formation on demand: An organocatalytic cross-coupling reaction of aldehydes with N-hydroxyimides, hexafluoroisopropyl alcohol, and sulfonimides has been developed. The resulting active intermediates can be directly converted into amides or esters in one pot. This simple method makes use of readily available starting materials, and the newly discovered activating reagents should find broad application in the synthesis of amides and esters.