Uteroferrin has N-asparagine-linked high-mannose-type oligosaccharides that contain mannose 6-phosphate.
Uteroferrin has N-asparagine-linked high-mannose-type oligosaccharides that contain mannose 6-phosphate.
复制标题
子宫铁蛋白具有 N-天冬酰胺连接的高甘露糖型寡糖，其中含有 6-磷酸甘露糖。
DOI：
10.1073/pnas.81.10.2985
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发表时间：
1984
影响因子：
11.1
通讯作者：
Roberts,RM
中科院分区：
文献类型：
--
作者：
Baumbach,GA;Saunders,PT;Bazer,FW;Roberts,RM
子宫铁蛋白是一种由孕酮诱导的含铁酸性磷酸酶，由猪的子宫内膜大量分泌。在怀孕期间，它运输铁穿过绒毛膜尿囊（胎盘）用于胎儿造血。在本文中，据报道，子宫铁蛋白合成培养的子宫内膜外植体具有N-连接，高甘露糖，寡糖链，含有6-磷酸甘露糖单位。后者被认为是一种可能的识别标志物，从而使酸性水解酶靶向溶酶体。然而，在子宫铁蛋白上，大多数磷酸盐是在甘露糖和覆盖的N-乙酰葡糖胺之间的单二酯键中。这表明，子宫铁蛋白是一种溶酶体酶，已承担了铁的运输和代谢的作用，并分泌，因为覆盖N-乙酰葡糖胺没有被删除。
Uteroferrin is an iron-containing, progesterone-induced, acid phosphatase that is secreted in large amounts by the uterine endometrium of pigs. During pregnancy, it transports iron across the chorioallantois (placenta) for use in fetal hematopoiesis. In this paper, it is reported that uteroferrin synthesized by cultured endometrial explants possesses N-linked, high-mannose, oligosaccharide chains that contain 6- phosphomannose units. The latter is regarded as a possible recognition marker whereby acid hydrolases are targeted to the lysosome. On uteroferrin, however, the majority of the phosphate is in single diester linkages between the mannose and a covering N-acetylglucosamine. It is suggested that uteroferrin is a lysosomal enzyme that has assumed a role in iron transport and metabolism and is secreted because the covering N-acetylglucosamine is not removed.