Evaluation of an efficient compensation method for quantitative fan-beam brain SPECT reconstruction.
Evaluation of an efficient compensation method for quantitative fan-beam brain SPECT reconstruction.
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定量扇束脑 SPECT 重建有效补偿方法的评估。
DOI：
10.1109/tmi.2004.839365
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发表时间：
2005
影响因子：
10.6
通讯作者：
Liang,Zhengrong
中科院分区：
文献类型：
--
作者：
Li,Tianfang;Wen,Junhai;Han,Guoping;Lu,Hongbing;Liang,Zhengrong
扇束准直器旨在提高单光子发射计算机断层扫描 (SPECT) 中人脑和乳房等小物体成像的系统灵敏度和分辨率。人们已经研究了许多重建算法并将其应用于该几何形状以处理各种退化因素。这项工作提出了一种新的圆形轨道 SPECT 重建方法，在精度和效率方面都表现出了良好的性能。新方法补偿了退化因素，包括噪声、散射、衰减和空间变化的探测器响应。其均匀衰减近似策略避免了对脑衰减图进行额外的透射扫描，从而减少了患者的辐射剂量，并进一步简化了成像过程。我们使用蒙特卡罗模拟来评估这种新方法，并将其与完善的有序子集期望最大化迭代方法进行比较。我们对这两种方法进行了区域偏差-方差、接收者操作特征和霍特林追踪研究的定量分析。结果表明，我们的重建策略具有可比的性能，并且显着减少了计算时间。
Fan-beam collimators are designed to improve the system sensitivity and resolution for imaging small objects such as the human brain and breasts in single photon emission computed tomography (SPECT). Many reconstruction algorithms have been studied and applied to this geometry to deal with every kind of degradation factor. This work presents a new reconstruction approach for SPECT with circular orbit, which demonstrated good performance in terms of both accuracy and efficiency. The new approach compensates for degradation factors including noise, scatter, attenuation, and spatially variant detector response. Its uniform attenuation approximation strategy avoids the additional transmission scan for the brain attenuation map, hence reducing the patient radiation dose and furthermore simplifying the imaging procedure. We evaluate and compare this new approach with the well-established ordered-subset expectation-maximization iterative method, using Monte Carlo simulations. We perform quantitative analysis with regional bias-variance, receiver operating characteristics, and Hotelling trace studies for both methods. The results demonstrate that our reconstruction strategy has comparable performance with a significant reduction of computing time.