Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia
Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia
复制标题
吡拉西坦对器质性痴呆患者局部脑血流及精神功能的影响
作者：
L. Gustafson;J. Risberg;M. Johanson;M. Fransson;V. Maximilian
研究吡拉西坦（Nootropil®，UCB 6215）对8例表现出中度痴呆症状的老年患者的心理功能和局部脑血流量（rCBF）的影响。双盲交叉设计包括9个测量场合，每个场合都包括133-Xe吸入法测量rCBF、痴呆症状评分、人格改变和副作用，以及心理测量学调查。三个治疗期各纳入三项调查。在一个时期内的第一次调查是在没有药物的情况下进行的。然后在四周内给予安慰剂或吡拉西坦4.8 g/天或9.6 g/天，分别在2周和4周后进行测量。治疗期之间有4周不用药的间隔。吡拉西坦对精神功能和rCBF均无显著影响。
The effects of piracetam (Nootropil®, UCB 6215) on mental functions and on regional cerebral blood flow (rCBF) were investigated in eight patients in the presenile age who displayed symptoms of moderate dementia. The double-blind crossover design included nine measurement occasions, each involving rCBF measurement by the 133-Xe inhalation method, ratings of symptoms of dementia, personality changes, and side effects, and a psychometric investigation. Three investigations were included in each of three treatment periods. The first investigation in a period was made without medication. Then either placebo or piracetam 4.8 g/day or 9.6 g/day was given during four weeks with measurements after 2 weeks and 4 weeks. There were intervals of 4 weeks without medication between the treatment periods. Piracetam had no significant effect on either mental functions or rCBF.