Experimental colitis as a promoter in large-bowel tumorigenesis.
Experimental colitis as a promoter in large-bowel tumorigenesis.
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实验性结肠炎作为大肠肿瘤发生的促进者。
DOI：
10.1001/archsurg.1982.01380340036009
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发表时间：
1982
影响因子：
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通讯作者：
P. Hagihara
中科院分区：
文献类型：
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作者：
P. Hagihara
为研究醋酸性结肠炎对1，2-二甲基肼诱导的结肠肿瘤发生的影响，将10周龄的fischer 344雄性大鼠分为3组：一组接受5%醋酸灌肠（亚组1a）;一组接受10%醋酸灌肠（亚组1b）;一组未接受醋酸灌肠（组2）。第1a组和第1b组的大鼠出现结肠炎，在某些情况下导致早期死亡。所有三组大鼠从11周龄开始接受相同剂量的二甲基肼皮下注射，每周一次，持续20周;在第一次二甲基肼注射后31周处死。在亚组1b中大肠中具有肿瘤的动物的百分比最大，在组2中最小。确定各组中每只动物大肠肿瘤的平均数量，其中大肠已经发育。亚组1的平均数量大于组2，也大于组1a和组2的总和。研究结果表明，结肠粘膜损伤可能使结肠上皮对粪便流中的致癌物诱发肿瘤敏感。
To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2). Colitis developed in rats in groups 1a and 1b, resulting in early death in some cases. Rats of all three groups received the same subcutaneous dose of dimethylhydrazine given once a week for 20 weeks starting at 11 weeks of age; they were killed at 31 weeks after the first dimethylhydrazine injection. The percentage of animals having tumors in the large bowel was greatest in subgroup 1b and least in group 2. The mean number of large-bowel tumors per animal in which large-bowel had developed was determined in each group. The mean number of subgroup 1 was greater than that of group 2 and also greater than that of groups 1a and 2 combined. The results of the study suggest that colonic mucosal injury may render the colonic epithelium susceptible to tumor induction by carcinogens in the fecal stream.