Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995-March 1998
Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995-March 1998
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DOI：
10.1017/s095026880200729x
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发表时间：
2002-08-01
影响因子：
4.2
通讯作者：
Crowcroft, NS
中科院分区：
文献类型：
--
作者：
M端ller-Pebody, B;Edmunds, WJ;Crowcroft, NS
需要估计因特定病原体而住院的人数，以预测疫苗接种的潜在影响。本文回顾了1995 ~ 1998年英国5岁以下儿童下呼吸道感染（LRI）的所有住院病例。大多数入院（76.8%）与特定微生物无关。使用多元线性回归，利用引起细支气管炎和肺炎的病原体的季节性来预测归因于不同生物体的不明病因病例的比例。在12298例LRI住院患者中，17.5%是由于RSV感染。估计74.8%（95% CI，72.0-77.7%）的“未指明的细支气管炎”入院和16.3%（95% CI，13.7-18.8%）的I类未指明的肺炎入院与RSV相关。RSV导致的住院总平均年发病率为28.3/1000 < 1岁儿童，1.3/1000 1-4岁儿童。通过应用简单的统计方法，显示RSV感染的负担大于出院数据所示的负担。
Estimates of the number of hospitalizations attributable to specific pathogens are required to predict the potential impact of vaccination. All hospital admissions for lower respiratory tract infection (LRI) in children < 5 years in England in 1995-8 were reviewed. Most admissions (76.8%) were not associated with specific organisms. Seasonality in pathogens that cause bronchiolitis and pneumonia was used to predict the proportion of cases with unspecified aetiology attributable to different organisms using multiple linear regression. Of 12298 admissions for LRI, 17.5% were due to RSV infection. An estimated 74.8% (95% CI, 72.0-77.7%) of 'unspecified bronchiolitis' admissions and 16.3% (95% CI, 13.7-18.8%) of I unspecified pneumonia' admissions were RSV related. The total mean annual incidence of hospital admissions attributable to RSV is 28.3/1000 children < 1 year of age, and 1.3/1000 children 1-4 years old. The greater burden of RSV infection than indicated through discharge data is revealed through applying simple statistical methods.