Association between periodontitis and anti-cardiolipin antibodies in Buerger disease
Association between periodontitis and anti-cardiolipin antibodies in Buerger disease
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DOI：
10.1111/j.1600-051x.2009.01467.x
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发表时间：
2009-10-01
影响因子：
6.7
通讯作者：
Izumi, Yuichi
中科院分区：
文献类型：
--
作者：
Chen, Yi-Wen;Nagasawa, Toshiyuki;Izumi, Yuichi
P&gT；抗心磷脂(CL)抗体可以在Buerger病(BD)中诱导，BD是一种影响周围血管的炎性闭塞性疾病，其反应是与磷脂结合的血浆蛋白β2-糖蛋白I的TLRVYK肽具有同源性的细菌。TLRVYK同源性存在于牙龈卟啉单胞菌(TLRIYT)和齿密螺旋体(TLALYK)。本研究调查了BD患者牙周感染与抗CL抗体之间的关系。材料和方法对19例BD患者和25名系统健康对照受试者进行了牙周状况检查。所有受试者都是重度吸烟者。结果BD患者牙周炎患病率明显高于健康对照组，牙周破坏严重，血清抗CL、抗TLRVYK、抗TLRIYT、抗TLALYK抗体滴度升高。抗CL抗体水平与3种抗肽抗体水平呈正相关。抗CL抗体滴度与BD患者临床附着水平<gt；=4 mm的部位百分比显著相关。结论抗CL抗体水平升高与BD患者牙周破坏有关。牙周病细菌可能作为外源性抗原，通过细菌肽与宿主血浆蛋白之间的分子模拟，刺激抗CL抗体的产生。
P>AimAnti-cardiolipin (CL) antibodies can be induced in Buerger disease (BD), an inflammatory occlusive disorder affecting peripheral blood vessels, in response to bacteria bearing homology to the TLRVYK peptide of a phospholipid-binding plasma protein beta-2-glycoprotein I. TLRVYK homologies are present in Porphyromonas gingivalis (TLRIYT) and Treponema denticola (TLALYK). This study investigated the association between periodontal infection and anti-CL antibodies in BD patients.Material and MethodsPeriodontal conditions were examined in 19 BD patients and 25 systemically healthy control subjects. All subjects were heavy smokers. Serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies were assessed using the enzyme-linked immunosorbent assay.ResultsBD patients had a significantly higher prevalence of periodontitis, more severe periodontal destruction and increased titres of serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies compared with healthy subjects. The levels of anti-CL antibodies positively correlated with those of the three anti-peptide antibodies. Anti-CL antibody titres were significantly associated with the percentage of sites with clinical attachment level >= 4 mm in BD patients.ConclusionElevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein.