Do quality of life assessments make a difference in the evaluation of cancer treatments?
Do quality of life assessments make a difference in the evaluation of cancer treatments?
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DOI：
10.1016/s0197-2456(97)00054-8
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发表时间：
1997-08-01
期刊：
影响因子：
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通讯作者：
Moinpour, CM
中科院分区：
文献类型：
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作者：
Moinpour, CM
这套生活质量报告提出的问题是，癌症临床试验中的生活质量评估是否有助于评估癌症治疗对患者功能的影响。在这次讨论中，重点讨论了缺失数据的问题，特别是那些在晚期疾病试验中常见的问题。鼓励研究人员调查与缺失数据相关的偏差程度，并相应地选择分析方法。在最糟糕的情况下，可能无法纵向分析数据；数据的描述性或图形化描述可能更合适。临床试验研究强调了仪器可靠性(将测量误差降至最低)的重要性，特别是在提高试验通过治疗臂检测生活质量差异的能力方面。根据缺失数据对生活质量问卷测量特性的影响来评估一种解决缺失数据的策略。临床试验小组已经成功地获得了多地点环境下的生活质量数据，患者总体上赞赏纳入治疗对其功能影响的系统和标准化报告的努力。(C)Elsevier Science Inc.1997。
The question posed by this set of quality of life papers is whether or not quality of life assessments in cancer clinical trials help evaluate the effects of cancer treatment on patient functioning. In this discussion, missing data problems, particularly those commonly found in advanced stage disease trials, are highlighted. Researchers are encouraged to investigate the extent of bias associated with missing data and to select analysis approaches accordingly. In the worst case, it may not be possible to analyze data longitudinally; descriptive or graphical portrayals of the data may be more appropriate. The importance of instrument reliability (minimizing measurement error) is emphasized for clinical trials research, particularly with respect to enhancing a trial's ability to detect quality of life differences by treatment arm. One strategy for addressing missing data is evaluated with respect to its impact on the measurement properties of the quality of life questionnaire. Clinical trials groups have been successful in obtaining quality of life data in multi-site settings and patients, by and large, appreciate the effort to include a systematic and standardized report of the effects of treatment on their functioning. (C) Elsevier Science Inc. 1997.