Layer-specific excitation/inhibition balances during neuronal synchronization in the visual cortex
Layer-specific excitation/inhibition balances during neuronal synchronization in the visual cortex
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DOI：
10.1113/jp274986
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发表时间：
2018-05-01
影响因子：
5.5
通讯作者：
Adesnik, Hillel
中科院分区：
文献类型：
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作者：
Adesnik, Hillel
节律活动可以同步皮质层内和皮质层之间的神经集合。虽然伽马波段的节律性已被观察到在所有层，层源和功能的影响，在皮层神经元同步仍然不完全理解。在这里，层特异性光遗传学刺激表明，小鼠初级视觉皮层的任何皮层层中的兴奋性神经元群体足以有力地夹带γ波段中的神经元振荡。在每一层中，抑制平衡兴奋并保持活动受到控制。跨层，跨层输出克服抑制并驱动下游点火。这些数据表明，节奏产生电路存在于所有的原则层的皮层，但提供层特定的兴奋和抑制的平衡，可以动态地塑造通过皮层电路的信息流。这些数据可能有助于解释皮质层之间的兴奋/抑制（E/I）平衡如何塑造信息处理，并揭示皮质伽马节律的不同性质和功能影响。
Rhythmic activity can synchronize neural ensembles within and across cortical layers. While gamma band rhythmicity has been observed in all layers, the laminar sources and functional impacts of neuronal synchronization in the cortex remain incompletely understood. Here, layer-specific optogenetic stimulation demonstrates that populations of excitatory neurons in any cortical layer of the mouse's primary visual cortex are sufficient to powerfully entrain neuronal oscillations in the gamma band. Within each layer, inhibition balances excitation and keeps activity in check. Across layers, translaminar output overcomes inhibition and drives downstream firing. These data establish that rhythm-generating circuits exist in all principle layers of the cortex, but provide layer-specific balances of excitation and inhibition that may dynamically shape the flow of information through cortical circuits. These data might help explain how excitation/inhibition (E/I) balances across cortical layers shape information processing, and shed light on the diverse nature and functional impacts of cortical gamma rhythms.