Ultra-widefield and high-speed spiral laser scanning OR-PAM: System development and characterization.
Ultra-widefield and high-speed spiral laser scanning OR-PAM: System development and characterization.
复制标题
超宽视场高速螺旋激光扫描 OR-PAM：系统开发和表征。
DOI：
10.1002/jbio.202200383
复制
发表时间：
2023
影响因子：
2.8
通讯作者：
Avanaki,Kamran
中科院分区：
文献类型：
--
作者：
Zafar,Mohsin;Manwar,Rayyan;McGuire,LauraS;Charbel,FadyT;Avanaki,Kamran
光声显微镜(PAM)是一种主要用于小视场应用的高分辨率成像技术。在这里，我们开发了一种快速的PAM系统，它利用了独特的螺旋激光扫描机制和宽声探测单元。所研制的系统可以对12.5cm2×6.4 S的面积进行成像。该系统已使用非常详细的体模进行了表征。最后，通过对体外羊脑和体内大鼠脑的成像实验，进一步验证了该系统的成像能力。
Photoacoustic microscopy (PAM) is a high‐resolution imaging modality that has been mainly implemented with small field of view applications. Here, we developed a fast PAM system that utilizes a unique spiral laser scanning mechanism and a wide acoustic detection unit. The developed system can image an area of 12.5 cm2in 6.4 s. The system has been characterized using highly detailed phantoms. Finally, the imaging capabilities of the system were further demonstrated by imaging a sheep brain ex vivo and a rat brain in vivo.