Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?
Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?
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DOI：
10.1039/d0cc03548c
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发表时间：
2020-09-04
影响因子：
4.9
通讯作者：
O'Connor, Peter B.
中科院分区：
文献类型：
--
作者：
Lam, Yuko P. Y.;Chiu, Cookson K. C.;O'Connor, Peter B.
脱酰胺淀粉样蛋白已被证明能加速纤维的形成。研究结果表明，脱酰胺对抑制性能和位点特异性抑制剂与淀粉样蛋白的相互作用位点有显著影响；而非位点特异性抑制剂的抑制机制未显示出淀粉样蛋白脱酰胺引起的明显破坏。
Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.