Using OPM-MEG in contrasting magnetic environments.
Using OPM-MEG in contrasting magnetic environments.
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DOI：
10.1016/j.neuroimage.2022.119084
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发表时间：
2022-06
期刊：
影响因子：
5.7
通讯作者：
Brookes, Matthew J.
中科院分区：
文献类型：
--
作者：
Hill, Ryan M.;Devasagayam, Jasen;Holmes, Niall;Boto, Elena;Shah, Vishal;Osborne, James;Safar, Kristina;Worcester, Frank;Mariani, Christopher;Dawson, Eliot;Woolger, David;Bowtell, Richard;Taylor, Margot J.;Brookes, Matthew J.
脑磁图（MEG）已经被光泵磁力计（OPMs）彻底改变。“OPM-MEG“比基于超导量子干涉器件（SQUID）的传统仪器具有更高的灵敏度、更好的空间分辨率和更低的成本。此外，由于OPM体积小，重量轻，便携式，它们提供了寿命合规性和（控制背景场）运动鲁棒性的可能性，大大扩展了MEG应用的范围。然而，OPM-MEG仍然是新兴技术;它对磁屏蔽提出了严格的要求，虽然存在许多可行的系统，但大多数都是定制的，并且没有跨站点调查显示数据的可靠性。在本文中，我们进行了第一次跨站点的OPM-MEG比较，使用几乎相同的商业系统扫描同一参与者。这两个站点故意形成对比，具有不同的磁环境：一个“绿色场“校园大学站点具有OPM优化的屏蔽室（低干扰），一个市中心医院站点具有“标准“（非优化）MSR（高干扰）。我们表明，尽管在背景场的20倍的差异，和30倍的差异，在低频干扰，使用动态场控制和基于软件的抑制干扰，我们可以在两个站点产生可比的噪声本底。在视觉运动任务和面部处理范式期间记录的人类数据中，我们能够生成类似的数据，源定位显示大脑区域可以精确定位，空间差异仅为~10 mm，时间相关性> 80%。总的来说，我们的研究表明，通过适当的现场控制，OPM-MEG系统甚至可以安装在市中心医院的位置。所介绍的方法为更广泛地部署OPM-MEG铺平了道路。
Magnetoencephalography (MEG) has been revolutionised by optically pumped magnetometers (OPMs). “OPM-MEG ” offers higher sensitivity, better spatial resolution, and lower cost than conventional instrumentation based on superconducting quantum interference devices (SQUIDs). Moreover, because OPMs are small, lightweight, and portable they offer the possibility of lifespan compliance and (with control of background field) motion robustness, dramatically expanding the range of MEG applications. However, OPM-MEG remains nascent technology; it places stringent requirements on magnetic shielding, and whilst a number of viable systems exist, most are custom made and there have been no cross-site investigations showing the reliability of data. In this paper, we undertake the first cross-site OPM-MEG comparison, using near identical commercial systems scanning the same participant. The two sites are deliberately contrasting, with different magnetic environments: a “green field ” campus university site with an OPM-optimised shielded room (low interference) and a city centre hospital site with a “standard ” (non-optimised) MSR (higher interference). We show that despite a 20-fold difference in background field, and a 30-fold difference in low frequency interference, using dynamic field control and software-based suppression of interference we can generate comparable noise floors at both sites. In human data recorded during a visuo-motor task and a face processing paradigm, we were able to generate similar data, with source localisation showing that brain regions could be pinpointed with just ~10 mm spatial discrepancy and temporal correlations of > 80%. Overall, our study demonstrates that, with appropriate field control, OPM-MEG systems can be sited even in city centre hospital locations. The methods presented pave the way for wider deployment of OPM-MEG.
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影响因子：
5.7
作者：
Holmes N;Leggett J;Boto E;Roberts G;Hill RM;Tierney TM;Shah V;Barnes GR;Brookes MJ;Bowtell R
通讯作者：
Bowtell R
影响因子：
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通讯作者：
Brookes MJ
影响因子：
5.7
作者：
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影响因子：
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作者：
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通讯作者：
Romalis, MV
影响因子：
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作者：
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通讯作者：
Cheyne, Douglas