Microstructural insight into inhalation powder blends through correlative multi-scale X-ray computed tomography
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray computed tomography
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DOI：
10.1016/j.ejpb.2023.08.016
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发表时间：
2023-09-16
影响因子：
4.9
通讯作者：
Murnane, Darragh
中科院分区：
文献类型：
--
作者：
Gajjar, Parmesh;Styliari, Ioanna Danai;Murnane, Darragh
干粉吸入器（DPI）对于局部药物递送到肺部很重要，但表征预雾化粉末微观结构是了解雾化后混合性能的关键初始步骤。在这项工作中，我们使用相关的多尺度x射线计算机断层扫描（XCT）表征了吸入混合物的预雾化3D微观结构，在同一样品上识别了多个长度尺度上的乳糖和富药物相。富药相在样品中的分布在整体尺度上是均匀的，但在颗粒尺度上是不均匀的，单个簇含有不同量的富药相，载体颗粒的不同部分被不同量的富药相包裹。用富药相厚度与载体粒径的简单标度法推导出药物配比与载体粒径的关系。这项工作为吸入粉末的微观结构评估打开了新的大门，这对干粉吸入器的生物等效性评估可能是无价的。
Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the preaerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. In this work, we characterise the pre-aerosolised 3D microstructure of an inhalation blend using correlative multi-scale X-ray Computed Tomography (XCT), identifying lactose and drug-rich phases at multiple length scales on the same sample. The drug-rich phase distribution across the sample is shown to be homogeneous on a bulk scale but heterogeneous on a particulate scale, with individual clusters containing different amounts of drug-rich phase, and different parts of a carrier particle coated with different amounts of drug-rich phase. Simple scalings of the drug-rich phase thickness with carrier particle size are used to derive the drugproportion to carrier particle size relationship. This work opens new doors to micro-structural assessment of inhalation powders that could be invaluable for bioequivalence assessment of dry powder inhalers.