MEDULLARY SPONGE KIDNEY AND RENAL ACIDIFICATION DEFECT
MEDULLARY SPONGE KIDNEY AND RENAL ACIDIFICATION DEFECT
复制标题
DOI：
10.1038/ki.1984.38
复制
发表时间：
1984-01-01
影响因子：
19.6
通讯作者：
NIIJIMA, T
中科院分区：
文献类型：
--
作者：
HIGASHIHARA, E;NUTAHARA, K;NIIJIMA, T
Medullary sponge kindey (MSK) is one of the entities which comprises a subclass of renal cystic disorders. While the clinical signs, symptoms and radiological findings have been well documented in the past, the literature concerning renal function in these patients is relatively sparse. The purpose of the present studies was to examine the renal function in 11 patients with MSK and compare them to 7 healthy volunteers and 10 control patients with bilateral renal stones. Patients with MSK had normal GFR [glomerular filtration rate], RPF [renal plasma flow] and capacity to dilute urine; their urine concentrating ability was diminished. Urine pH in MSK patients was higher than in control patients with NH4Cl administration, while titratable acid excretion was lower than normal. Steady-state plasma HCO3- concentration was lower in MSK patients than in controls but arterial pH was within normal limits. MSK patients may have defects in urinary acidification and concentration mechanisms which may, in part, be the result of functional abnormality of the terminal collecting ducts.
