Human herpesvirus 8 detection in nasal secretions and saliva
Human herpesvirus 8 detection in nasal secretions and saliva
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DOI：
10.1086/517356
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发表时间：
1998-01-01
影响因子：
6.4
通讯作者：
Levy, JA
中科院分区：
文献类型：
--
作者：
Blackbourn, DJ;Lennette, ET;Levy, JA
用聚合酶链式反应(PCR)检测了14例HHV-8阳性者鼻腔分泌物和唾液中人类疱疹病毒8型(HHV-8)的存在，其中包括8例卡波西肉瘤患者，其中7例为人类免疫缺陷病毒1型感染，其中6例无症状。在14名受试者中，有8人(57%)在一个或两个体液中检测到HHV-8，平行PCR检测显示这些体液中同时存在巨细胞病毒、爱泼斯坦-巴尔病毒和HHV-6。这些数据表明，鼻腔分泌物和唾液中的多种疱疹病毒频繁脱落，尤其是在卡波西肉瘤患者中。因此，这两种体液都是HHV-8通过非性传播的潜在来源。
The presence of human herpesvirus 8 (HHV-8) was determined by polymerase chain reaction (PCR) in nasal secretions and saliva from 14 HHV-8-seropositive persons, including 8 Kaposi's sarcoma patients: 7 were human immunodeficiency virus type 1-infected, 6 of whom were asymptomatic. HHV-8 was detected in one or both body fluids in 8 (57%) of 14 subjects, Parallel PCR testing revealed the concomitant presence of cytomegalovirus, Epstein-Barr virus, and HHV-6 in various combinations in these body fluids. These data indicate frequent shedding of multiple herpesviruses in nasal secretions and saliva, particularly in Kaposi's sarcoma patients. Both body fluids are therefore potential sources HHV-8 by nonsexual transmission.