Animal models of emphysema and their relevance to studies of particle-induced disease
Animal models of emphysema and their relevance to studies of particle-induced disease
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DOI：
10.1080/089583700750019558
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发表时间：
2000-01-01
影响因子：
2.1
通讯作者：
Nikula, KJ
中科院分区：
文献类型：
--
作者：
March, TH;Green, FHY;Nikula, KJ
肺气肿是一种肺部疾病，吸入颗粒可能会加剧。多年来，已经开发出许多肺气肿动物模型，这些模型可能有助于研究吸入颗粒对肺气肿患者的影响。已在许多物种中描述了模型，并且已描述了许多用于诱导肺气肿的接近器。人类肺气肿是慢性阻塞性肺病的实质组成部分，并且经常与气道疾病（例如支气管炎）共存。肺气肿的动物模型通常仅概括这种复杂疾病的一个或几个方面。因此，必须仔细选择肺气肿模型，以回答有关颗粒和肺气肿相互作用的具体问题。
Emphysema is a pulmonary disease that may be exacerbated by inhaled particles. Over the years, many animal models of emphysema have been developed that may be useful in studying the effects of inhaled particles on humans with emphysema. Models have been described in many species, and many approacher have been described for inducing emphysema. Emphysema in humans is a parenchymal component of chronic obstructive pulmonary disease and frequently coexists in a complex with disease of the airways such as bronchitis. Animal models of emphysema usually recapitulate only one or a few aspects of this complex disease. Thus, the emphysema model must be selected carefully in order to answer specific questions about the interactive effects of particles and emphysema.