Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference
Naloxone Facilitates Extinction but Does Not Affect Acquisition or Expression of Ethanol-Induced Conditioned Place Preference
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DOI：
10.1037/1064-1297.3.4.330
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发表时间：
1995-11-01
影响因子：
2.3
通讯作者：
Okorn, Dobrina M.
中科院分区：
文献类型：
--
作者：
Cunningham, Christopher L.;Dickinson, Shelly D.;Okorn, Dobrina M.
小鼠（DBA/2J）接受巴甫洛夫程序，其中独特的地板刺激与乙醇（2 g/kg）配对4次。不同的地板刺激与盐水配对。纳洛酮（0.0，1.5，或10.0毫克/公斤，腹腔注射）之前，每个乙醇试验并没有干扰收购的条件性偏好，虽然纳洛酮单独产生条件性厌恶。当纳洛酮（0.0，0.15，1.5，3.0，或10.0 mg/kg）在测试期间第一次给予，小鼠在前10分钟内表现出条件性偏好。然而，偏好随后随时间呈剂量依赖性下降。对照研究消除了基于药代动力学或厌恶状态存在的替代解释。结果的整体模式表明，纳洛酮促进条件性位置偏爱的消退，并支持乙醇诱导的条件性强化是由内源性阿片系统介导的假设。
Mice (DBA/2J) received a Pavlovian procedure in which a distinctive floor stimulus was paired 4 times with ethanol (2 g/kg). A different floor stimulus was paired with saline. Naloxone (0.0, 1.5, or 10.0 mg/kg, intraperitoneal) given before each ethanol trial did not interfere with acquisition of conditioned preference, although naloxone alone produced conditioned aversion. When naloxone (0.0, 0.15, 1.5, 3.0, or 10.0 mg/kg) was given for the first time during testing, mice showed conditioned preference during the first 10 min. However, preference subsequently decreased dose-dependently over time. Control studies eliminated alternative interpretations based on pharmacokinetics or presence of an aversive state. The overall pattern of results suggests that naloxone facilitated extinction of conditioned place preference and supports the hypothesis that ethanol-induced conditioned reinforcement is mediated by the endogenous opioid system.