Spectrum Fusion: Using Multiple Mass Spectra for De Novo Peptide Sequencing
Spectrum Fusion: Using Multiple Mass Spectra for De Novo Peptide Sequencing
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DOI:
10.1089/cmb.2009.0122
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发表时间:
2009-08-01
影响因子:
1.7
通讯作者:
Bern, Marshall
中科院分区:
文献类型:
--
作者:
Datta, Ritendra;Bern, Marshall
We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that it can handle spectra from any instrument and fragmentation technique. We demonstrate the utility of the algorithm, and the power of multiple spectra, by showing that combining pairs of spectra (one CID and one ETD) greatly improves de novo sequencing success rates.