Loss of the Y chromosome in bone marrow cells: results on 1907 consecutive cases of leukaemia and preleukaemia
Loss of the Y chromosome in bone marrow cells: results on 1907 consecutive cases of leukaemia and preleukaemia
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DOI：
10.1046/j.1365-2257.1999.00173.x
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发表时间：
1999-02-01
期刊：
影响因子：
--
通讯作者：
Koulischer, L
中科院分区：
文献类型：
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作者：
Herens, C;Brasseur, E;Koulischer, L
Y染色体缺失导致45，XO核型在老年男性的正常骨髓细胞中观察到，但也在血液恶性肿瘤中观察到。肿瘤细胞中的Y丢失是否与正常衰老过程有关，还是致癌过程的一部分尚不清楚。本研究涉及1907例连续白血病或白血病前期男性患者的细胞遗传学数据，特别关注Y染色体的存在或缺失。65例（3.4%）患者的骨髓（BM）细胞中有45x -Y克隆。Y染色体缺失在50岁以下很少见，但在老年患者中有所增加，在80岁以上的男性中占25%。16例患者（0.08%）BM中XO细胞超过90%，其中7例Y缺失与白血病之间存在相关性，其中3例为急性髓系白血病M2亚型，已知-Y是次要事件。在另外三个案例中，-Y是复杂核型的一部分。只有一名患者表现出45，XO核型，没有其他重排，这可能与肿瘤过程呈正相关。
Loss of the Y chromosome with a resulting 45, XO karyotype is observed in normal bone marrow cells of elderly males but also in haematological malignancies. Whether Y loss in neoplastic cells is related to the process seen in normal ageing or is part of the carcinogenic process is unknown. The present study concerns the cytogenetic data from 1907 consecutive leukaemic or preleukaemic male patients with special regard to the presence or absence of the Y chromosome. Sixty-five patients (3.4%) had a 45, X -Y clone in their bone marrow (BM) cells. Loss of Y was rare below the age of 50 but increased in older patients, reaching 25% of the men over 80. Sixteen patients (0.08%) had more than 90% XO cells in their BM, A correlation between Y loss and leukaemia could be established in seven cases, three of which were acute myeloid leukaemia M2 subtype where -Y is known to be a secondary event. In three other cases, -Y was part of a complex karyotype. Only one patient exhibited a 45, XO karyotype, with no other rearrangement, that could be positively correlated with the neoplastic process.