ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states
ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states
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DOI：
10.1016/j.bbrc.2004.03.151
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发表时间：
2004-05-14
影响因子：
3.1
通讯作者：
Katayama, S
中科院分区：
文献类型：
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作者：
Inukai, K;Nakashima, Y;Katayama, S
血管生成素样蛋白3（ANGPTL 3）是由肝脏分泌的，最近被认为是调节血清甘油三酯水平的重要激素。在本研究中，为了阐明糖尿病状态下ANGPTL 3基因表达的调节，我们检测了糖尿病动物肝脏中ANGPTL 3的mRNA和蛋白水平。在链脲佐菌素（STZ）糖尿病小鼠的肝脏中，ANGPTL 3 mRNA水平增加约2.2倍，并且这种作用可通过给予胰岛素逆转。此外，ANGPTL 3 mRNA水平在2型糖尿病肥胖小鼠（db/db小鼠）中增加超过3.0倍，与年龄匹配的瘦同窝出生小鼠相比。在这些糖尿病小鼠中，ANGPTL 3蛋白的肝脏水平也增加到与ANGPTL 3 mRNA相似的程度。因此，ANGPTL 3的表达在胰岛素缺乏和胰岛素抵抗的糖尿病状态中均增强。这些结果强烈表明ANGPTL 3在糖尿病高脂血症中起重要作用。(C)2004年爱思唯尔公司All rights reserved.
Angiopoietin-like protein 3 (ANGPTL3) is secreted by the liver and was recently postulated to be an important hormone regulating serum triglyceride levels. In the present study, in order to clarify the regulation of ANGPTL3 gene expression in diabetic states, we examined mRNA and protein levels of ANGPTL3 in the livers of diabetic animals. The level of ANGPTL3 mRNA was increased approximately 2.2-fold in the livers of streptozotocin (STZ) diabetic mice, and this effect was reversed by administration of insulin. Furthermore, the level of ANGPTL3 mRNA was increased more than 3.0-fold in type 2 diabetic obese mice, db/db mice, as compared with age matched lean littermates. The hepatic level of ANGPTL3 protein was also increased in these diabetic mice to an extent similar to that of ANGPTL3 mRNA. Thus, the expression of ANGPTL3 was enhanced in both insulin-deficient and -resistant diabetic states. These results strongly suggest ANGPTL3 to play an important role in hyperlipidemia in diabetes. (C) 2004 Elsevier Inc. All rights reserved.