Hypothalamic control of male aggression-seeking behavior.
Hypothalamic control of male aggression-seeking behavior.
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DOI：
10.1038/nn.4264
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发表时间：
2016-04
影响因子：
25
通讯作者：
Lin D
中科院分区：
文献类型：
--
作者：
Falkner AL;Grosenick L;Davidson TJ;Deisseroth K;Lin D
在许多脊椎动物物种中，某些个体会寻找攻击的机会，即使没有威胁引发的线索。虽然有几个大脑区域参与了对社会威胁的攻击，但人们对在没有威胁的情况下促进自我发起或“自愿”攻击寻求的神经机制知之甚少。为了直接探索这一点，我们利用了一个寻求攻击的任务，其中雄性小鼠可以自我发起攻击试验，以获得简短和重复的访问一个较弱的男性，他们的攻击。在男性表现出快速任务学习，我们发现，腹内侧下丘脑（VMHvl），一个已知的作用，在攻击的区域，是必不可少的侵略寻求的腹外侧部分。使用单单位电生理学和群体光学记录，我们发现VMHvl神经元在攻击寻求过程中变得活跃，并且它们的活动跟踪任务学习和灭绝的变化。VMHvl的失活减少了攻击寻求行为，而VMHvl的光遗传学刺激加速了瞬间的攻击寻求并加剧了未来的攻击。这些数据表明，VMHvl可以调解急性攻击和灵活的寻求行动之前的攻击。
In many vertebrate species, certain individuals will seek out opportunities for aggression, even in the absence of threat provoking cues. While several brain areas have been implicated in generating attack in response to social threat, little is known about the neural mechanisms that promote self-initiated or “voluntary” aggression seeking when no threat is present. To explore this directly, we utilize an aggression-seeking task wherein male mice can self-initiate aggression trials to gain brief and repeated access to a weaker male that they attack. In males that exhibit rapid task learning, we find that the ventrolateral part of the ventromedial hypothalamus (VMHvl), an area with a known role in attack, is essential for aggression seeking. Using both single unit electrophysiology and population optical recording, we find that VMHvl neurons become active during aggression seeking and their activity tracks changes in task learning and extinction. Inactivation of the VMHvl reduces aggression-seeking behavior, whereas optogenetic stimulation of the VMHvl accelerates moment-to-moment aggression seeking and intensifies future attack. These data demonstrate that the VMHvl can mediate both acute attack and flexible seeking actions that precede attack.