Anthelmintic constituents of Clonostachys candelabrum
Anthelmintic constituents of Clonostachys candelabrum
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DOI：
10.1038/ja.2009.131
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发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Singh, Sheo B.
中科院分区：
文献类型：
--
作者：
Ayers, Sloan;Zink, Deborah L.;Singh, Sheo B.
从华支睾吸虫丙酮提取物中分离得到5个非对映异构体聚酮糖苷，即玫瑰脂苷3A-3E(1-5)，它们具有较强的驱虫活性。通过与已报道的玫瑰花苷及其相关结构的核磁共振和MS数据比较，确定了它们的结构，并用2D-核磁共振波谱进行了确证。已知的化合物亚油酸(6)和橙皮酚(7)也被分离出来作为驱虫活性成分，尽管远不如玫瑰脂类有效。《抗生素杂志》(2010年)63,119122；doi：10.1038/ja.2009.131；1月15日在线发布
Five diastereomeric polyketide glycosides, roselipins 3A-3E (1-5), have been isolated from the acetone extract of Clonostachys candelabrum on the basis of their positive anthelmintic activity. The structures of these compounds were elucidated by comparison of their NMR and MS data to those of previously reported roselipins and related structures, and were confirmed by 2D-NMR spectral analysis. Known compounds linoleic acid (6) and aurantiogliocladin (7) were also isolated as active anthelmintic components, although much less potent than the roselipins. The Journal of Antibiotics (2010) 63, 119-122; doi:10.1038/ja.2009.131; published online 15 January 2010