A study of reproductive performance in pregnant, IL-2 receptor beta-chain overexpressed transgenic mice.
A study of reproductive performance in pregnant, IL-2 receptor beta-chain overexpressed transgenic mice.
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一项对怀孕的 IL-2 受体 β 链过表达转基因小鼠的生殖性能的研究。
DOI：
10.1292/jvms.63.99
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Y. Kiso
中科院分区：
文献类型：
--
作者：
Y. Namba;E. Hondo;M. Morimoto;O. Nakamura;K. Kusakabe;M. Ito;S. Saito;E. Sagara;Y. Kiso
在妊娠的IL-2受体β链过表达转基因（Tg 2 R β）小鼠中研究了雌性生殖性能与子宫自然杀伤（uNK）细胞的关系。在妊娠第8天，所有胎仔均存活，表明这些小鼠中正常发生着床。然而，47%的胎儿在妊娠10天时死亡，在12天时所有胎儿都在吸收，表明胎儿丢失随着妊娠的进展而进展。Tg 2 R β小鼠胎盘重量随妊娠时间的延长而逐渐减轻。在第10天，Tg 2 R β小鼠的胎盘迷路、基底蜕膜和子宫腺发育不良，并且在Tg 2 R β小鼠中发现比对照小鼠更多的uNK细胞。我们建议Tg 2 RPbeta小鼠是uNK细胞可以导致流产的第一个有趣的模型，以澄清uNK细胞功能在女性生殖性能中的参与。
Relationships between female reproductive performance and uterine natural killer (uNK) cells were investigated in pregnant IL-2 receptor beta-chain overexpressed transgenic (Tg2Rbeta) mice. At 8 days of pregnancy, all fetuses were alive, suggesting that implantation normally occurred in these mice. However, 47% of fetuses were dead at 10 days of pregnancy and at 12 days all fetuses were resorbing, indicating that fetal loss progressed with the advance of pregnancy. The placenta of Tg2Rbeta mice gradually decreased in weight with the advance of pregnancy. At 10 days the placental labyrinth, decidua basalis, and metrial gland in Tg2Rbeta mice were poorly developed, and more uNK cells were found in Tg2Rbeta mice than in the control mice. We propose that Tg2RPbeta mice are the first and interesting model that uNK cells can cause abortion, to clarify the involvement of uNK cell function in female reproductive performance.