The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease
The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease
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DOI：
10.1093/cercor/1.1.103
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发表时间：
1991-01-01
期刊：
影响因子：
3.7
通讯作者：
Van Hoesen, Gary W.
中科院分区：
文献类型：
--
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
神经原纤维缠结（NFTS）和神经斑（NP）的分布在11个大脑的11个阿尔茨海默氏病（AD）的皮质区域中进行了映射。将整个半球块嵌入到聚乙烯乙二醇（carbowax）中，分割为冠状动脉，并用硫诺夫蛋白S和硫氨酸染色。使用每个区域的数值评级量表评估NFT和NP的密度。分数按皮层类型和LOBE进行分组，以进行统计分析。获得了高度显着的差异。例如，边缘周围皮层和同层比其他任何类型的皮质具有更多的NFT。按降顺序，NFT的密度如下：外层皮层（区域28）>同种皮质（海马形成的下区域/CA1区域，区域51）> corticoid> corticoioid区域（Amygdala的辅助基底核，Amygdala，Meynert of Meynert of Meynert）> ProisOcortex（Meynert of Meynert）> 11、12、24、23，前岛，38、35） >非主要关联皮层（32，46，上颞沟，40，39，后帕拉希峰皮层，37，36）>主要感觉缔合皮质（7,18,19，22，21,20）> agranular Cortex（44-5 ，8、6、4）>主要感觉皮层（41-2，3-1-2，17）。 NFT的层分布倾向于选择性，主要涉及临界区域以及边缘周围皮层的II和IV层的III和V。边缘和颞叶的NFT远远超过额叶，顶叶和枕叶。通常，NP在整个皮质中的分布更均匀，除边缘外层面和同层外，其NP的含量明显少于其他皮质区域。颞叶和枕叶的NP密度最高，边缘和额叶的叶具有最低，顶叶中间。在整个人群中没有发现明显的NFT或NP密度的明显左右半球差异，疾病的持续时间与NFTS或NP的密度之间没有关系。NFTS的区域和层状分布（在较小程度上，这是较小程度的NP）提出了脑皮质中脆弱性的一致模式，似乎与皮质皮质连接的层次结构相关。高阶关联皮层，尤其是颞叶前和腹侧部门的皮层，是最脆弱的，而其他皮质似乎不太容易与与其连接的“距离”（即移除突触）相称的程度。 。
The distribution of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) was mapped in 39 cortical areas of 11 brains of patients with Alzheimer's disease (AD). Whole hemisphere blocks were embedded in polyethylene glycol (Carbowax), sectioned coronally, and stained with thioflavin S and thionin. The densities of NFTs and NPs were assessed using a numerical rating scale for each area. Scores were grouped by type of cortex and by lobe for statistical analysis. Highly significant differences were obtained. For example, limbic periallocortex and allocortex had more NFTs than any other type of cortex. In descending order, the density of NFTs was as follows: periallocortex (area 28) > allocortex (subiculum/CA1 zones of hippocampal formation, area 51) > corticoid areas (accessory basal nucleus of amygdala, nucleus basalis of Meynert) > proisocortex (areas 11, 12, 24, 23, anterior insula, 38, 35) > nonprimary association cortex (32, 46, superior temporal sulcus, 40, 39, posterior parahippocampal cortex, 37, 36) > primary sensory association cortex (7,18,19, 22, 21,20) > agranular cortex (44-5, 8, 6, 4) > primary sensory cortex (41-2, 3-1-2, 17). The laminar distribution of NFTs tended to be selective, involving primarily layers III and V of association areas and layers II and IV of limbic periallocortex. There were far more NFTs in both limbic and temporal lobes than in frontal, parietal, and occipital lobes. In general, NPs were more evenly distributed throughout the cortex, with the exceptions of limbic periallocortex and allocortex, which had notably fewer NPs than other cortical areas. Temporal and occipital lobes had the highest NP densities, limbic and frontal lobes had the lowest, and parietal lobe was intermediate. No significant left-right hemispheric differences for NFT or NP densities were found across the population, and there was no relationship between duration of illness and densities of NFTs or NPs.The regional and laminar distribution of NFTs (and, to a lesser degree, that of NPs) suggests a consistent pattern of vulnerability within the cerebral cortices that seems correlated to die hierarchies of cortico-cortical connections. The higher-order association cortices, especially those in the anterior and ventromedial sectors of temporal lobe, are the most vulnerable, while other cortices appear less vulnerable to a degree commensurate with their connectional "distance" (i.e., synapses removed) from the limbic areas.