A new recommended dietary allowance of vitamin C for healthy young women
A new recommended dietary allowance of vitamin C for healthy young women
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DOI：
10.1073/pnas.171318198
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发表时间：
2001-08-14
影响因子：
11.1
通讯作者：
Morrow, J
中科院分区：
文献类型：
--
作者：
Levine, M;Wang, YH;Morrow, J
最近发布的女性维生素C每日推荐摄入量为75毫克，是基于男性的数据。我们现在报告一项消耗-补充研究的结果，健康的年轻女性住院186 +/- 28天，每天使用30- 2500 mg的维生素C剂量。剂量与稳态血药浓度之间呈S形关系。仅高于100 mg的剂量超出曲线的线性部分。血浆和循环细胞在每天400 mg时饱和，尿液消除较高剂量。内源性氧化应激的生物标志物、血浆和尿液F-2-异前列烷以及F-2-异前列烷主要代谢物的尿液水平在所有剂量下均未被维生素C改变，表明这种维生素不会改变健康年轻女性的内源性脂质过氧化。通过使用食品和营养委员会的指导方针，数据表明，年轻女性的建议膳食津贴应增加到每天90毫克。
The recently released Recommended Dietary Allowance of vitamin C for women, 75 mg daily, was based on data for men. We now report results of a depletion-repletion study with healthy young women hospitalized for 186 +/- 28 days, using vitamin C doses of 30-2,500 mg daily. The relationship between dose and steady-state plasma concentration was sigmoidal. Only doses above 100 mg were beyond the linear portion of the curve. Plasma and circulating cells saturated at 400 mg daily, with urinary elimination of higher doses. Biomarkers of endogenous oxidant stress, plasma and urine F-2-isoprostanes, and urine levels of a major metabolite of F-2-isoprostanes were unchanged by vitamin C at all doses, suggesting this vitamin does not alter endogenous lipid peroxidation in healthy young women. By using Food and Nutrition Board guidelines, the data indicate that the Recommended Dietary Allowance for young women should be increased to 90 mg daily.